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Atomoxetine (brand name: Strattera) is a norepinephrine reuptake inhibitor approved for the treatment of stimulant treatments for ADHD is that it has little known abuse potential.

The initial therapeutic effects of atomoxetine usually take 2–4 weeks to be become apparent.A further 2–4 weeks may be required for the full therapeutic effects to be seen.Its efficacy may be less than that of stimulant medications^.

Unlike α2 adrenoceptor agonists such as guanfacine and clonidine, atomoxetines use can be abruptly stopped without significant withdrawal effects being seen.

Investigational uses

There has been some suggestion that atomoxetine might be a helpful adjunct in people with major depression, especially in cases where ADHD occurs comorbidly to major depression.Several randomised double-blind placebo-controlled trials found that atomoxetine was an efficacious treatment for various disorders like paediatric bedwetting,binge eating disorder,and is an efficacious weight loss medication.